Amiloride — what it does and why people take it

Amiloride is a potassium-sparing diuretic used to treat high blood pressure, fluid buildup (edema), and specific conditions like Liddle syndrome. Unlike many diuretics that make you lose potassium, amiloride helps your body keep potassium while removing extra salt and water. That small difference can prevent the annoying and dangerous drop in potassium some people get on other diuretics.

How amiloride works and usual dosing

Amiloride blocks sodium channels in the kidney so less sodium is reabsorbed and less potassium is lost. Typical doses for adults are 5–10 mg once daily. Some patients need up to 20 mg per day split into two doses, but your doctor will choose the right amount. It’s often combined with a thiazide diuretic (like hydrochlorothiazide) to balance potassium levels while still getting good water loss.

Take amiloride at the same time each day. You can take it with or without food. If you miss a dose, take it when you remember unless it’s almost time for the next dose — then skip the missed one. Don’t double up.

Safety: what to watch for and tests you’ll need

The main risk is high potassium (hyperkalemia). Symptoms include weakness, tingling, or an irregular heartbeat. People with kidney disease, diabetes, or those taking ACE inhibitors, ARBs, potassium supplements, salt substitutes, or certain antibiotics like trimethoprim are at higher risk. NSAIDs can also reduce kidney function and raise potassium risk.

Your provider will check blood tests after starting or changing the dose — usually within a week — and then periodically after that. A normal potassium range is about 3.5–5.0 mEq/L; values above 5.5 mEq/L are concerning. Tell your doctor about any herbal supplements, OTC drugs, or diet changes (like using salt substitutes) because they can change potassium levels.

Other side effects can include nausea, headache, dizziness, or dehydration. If you feel faint, have severe belly pain, or notice a fast or irregular heartbeat, get medical help fast.

Pregnant or breastfeeding? Talk to your clinician. They’ll weigh benefits and risks and may choose a different treatment.

Buying meds online? Only use licensed pharmacies that require a prescription and show clear contact details and professional credentials. Scams and counterfeit drugs are common on shady sites.

Storage is simple: keep tablets at room temperature away from moisture and kids. Don’t stop amiloride suddenly without checking with your prescriber — blood pressure or fluid status can change.

If you want practical next steps: ask your doctor how often to check potassium and kidney tests, list all other meds before starting, and avoid potassium-rich salt substitutes unless approved. These small steps cut risk and help amiloride work as intended.