Think hepatitis C always needed long, harsh treatment? Daclatasvir helped change that by being part of short, well-tolerated regimens that actually cure many people. If your doctor mentioned daclatasvir (an NS5A inhibitor), here’s what you need to know in plain language — how it works, how people take it, and the main safety points to watch.
Daclatasvir is a direct-acting antiviral that targets the hepatitis C virus protein NS5A. That protein helps the virus copy and assemble itself. Block NS5A, and the virus can’t spread inside your liver cells as well. Daclatasvir is taken by mouth, usually once a day, and rarely used alone. Doctors combine it with another antiviral such as sofosbuvir or with a multi-drug DAA regimen. Treatment length depends on your virus genotype, liver health, and whether you’ve been treated before — common courses run 8 to 12 weeks but can be longer in some cases.
Before starting, your provider will check your liver tests, viral load, and other meds you take. That helps pick the best combination and treatment length. Don’t stop or skip pills — doing so can lower your chance of cure and raise resistance risk.
Most people tolerate daclatasvir well. The more common side effects reported are fatigue, headache, and nausea. Serious problems are uncommon, but any new jaundice, dark urine, severe fatigue, or abdominal pain should be reported right away — those can signal liver trouble.
Drug interactions matter. Daclatasvir is affected by drugs that change CYP3A activity. Strong CYP3A inducers (for example, rifampin or certain seizure meds) can lower daclatasvir levels and make it less effective. Strong CYP3A inhibitors can raise levels and increase side effects. Your doctor or pharmacist should review every medicine, herbal product, and supplement you take before treatment.
Pregnancy and breastfeeding require a talk with your clinician. Some treatment partners have specific pregnancy rules, so planning is important if you or your partner might be pregnant. Also, if you have severe liver impairment, dosing and choices change — your specialist will guide that.
Finally, beware of buying medicines from unverified online sources. Authentic, regulated supply is crucial for real results and safety. If paying out of pocket is an issue, ask your provider about patient assistance programs or local services that help access treatment affordably.
If you want a quick checklist: confirm your genotype and liver tests, list all meds, expect a daily oral pill usually paired with another DAA, watch for common mild side effects, and report any signs of liver trouble immediately. Always follow your clinician’s plan — they’ll tailor the regimen to give you the best shot at a cure.
This article sheds light on Daclatasvir, an effective medication used in the treatment of Hepatitis C. It explores how the drug works, its benefits, side effects, and some handy tips for patients. It's packed with useful information designed to help readers understand this important treatment option.